Posts Tagged ‘ACE inhibitors’

Continue, stop, or start ACE inhibitors before cardiac surgery?

Tuesday, July 17th, 2012

Keep your neo/vasopressin handy and deal with it!

A new retrospective study of 4000+ cardiac surgery patients shows that the periop use of ACE-I is associated with reduced morbid events; the primary outcome of the study was defined as the composite outcome of the cardiac, cerebral, and renal events and in-hospital mortality:

“CONCLUSIONS: Our study suggests that withdrawal of ACEI treatment after CABG surgery is associated with non-fatal in-hospital ischemic events. Further, continuation of ACEI or de novo ACEI therapy early after cardiac surgery is associated with improved in-hospital outcomes.”

So, keep your neo/vasopressin handy and deal with it!

Figure 2.

Kaplan–Meier survival analysis of event-free status by angiotensin-converting enzyme inhibitor (ACEI) therapy. The curves show data of 30-day in-hospital composite event-free status. The P value shown is for the comparison of Kaplan–Meier survival function among the 4 groups. The P value was calculated from the log-rank